Ischemic Tolerance in Uremic Rabbits

Ischemic Tolerance in Uremic Rabbits

Background: Cardiac complications after myocardial infarction are believed to be worse in the presence of comorbidities; we tested whether experimentally induced prolonged uremia exacerbated myocardial necrosis in a rabbit preparation of ischemia-reperfusion injury. In addition, we examined if treatment with an angiotensin converting enzyme inhibitor (Enalapril, ENA, 3 mg/Kg, IV) could reduce p...

The uremic myocardium and ischemic tolerance: a world of difference.

Uremia is associated with an increased prevalence of ischemic heart disease. Already, at the start of dialysis, the prevalence of coronary artery disease is 38%.1 The frequency of myocardial infarction in renal patients is high and the outcome is poor.2 Despite significant improvement of therapeutic modalities, the unadjusted 2-year mortality for dialysis patients after acute myocardial infarct...

The Uremic Myocardium and Ischemic Tolerance : A World of Difference Running title :

Urea Tolerance after Unilateral Nephrectomy in Rabbits

The method of study has an objective somewhat different from, and lacking the precision of, the ratio of Addis and the urea clearance of Van Slyke. It serves, however, to demonstrate that although for a month after unilateral nephrectomy the remaining kidney shows diminished capacity to hold blood urea within the normal range, nevertheless after 4 months this function is maintained in essential...

Increased infarct size in uremic rats: reduced ischemia tolerance?

In patients with renal failure, myocardial infarction (MI) is more frequent and the rate of death from acute MI is very high. It has been argued that ischemia tolerance of the heart is reduced in uremia, but direct evidence for this hypothesis has not been provided. It was the purpose of this study (1) to ligate the left coronary artery and to measure the nonperfused area (risk area: total infa...